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Setmelanotide Setmelanotide is a melanocortin-4 receptor (MC4R) agonist approved to treat genetic obesity due to pro-opiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1 (PCSK1), or leptin receptor (LEPR) deficiencies, as well as Bardet–Biedl syndrome (BBS), in patients aged 2 years and older [45,46,47]
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