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Compounded semaglutide side effects Common and serious side effects of semaglutide include: Common side effects The most common side effects of compounded semaglutide include: Nausea Abdominal discomfort Stomach problems Constipation Vomiting Diarrhea Serious side effects Serious side effects of compounded semaglutide can include the following: Severe stomach problems Changes in vision (due to diabetic retinopathy) Acute pancreatitis Gallbladder problems Hypersensitivity/allergic reaction Hypoglycemia (low blood sugar levels) Mood and behavioral changes Suicidal ideation Acute kidney injury Increased risk of aspiration in anesthesia and sedation The mild side effects of compounded semaglutide usually subside over time