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Semaglutide, liraglutide, dulaglutide, and tirzepatide are all downstream descendants, pharmacologically speaking, of that lizard venom discovery in a Veterans Affairs laboratory in the 1980s
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In the early 1950's, Earl Sutherland and Christian de Duve demonstrated that pancreatic glucagon production was abolished when the function of islet α-cells was compromised by treatment with either cobalt or synthalin A but was preserved upon alloxan-induced impairment of the exocrine pancreatic acinar and islet β-cells [14,15]
